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Event ID : ADDF_SD
Alzheimers Drug Discovery Foundation
5th DRUG DISCOVERY FOR NEURODEGENERATION: An Intensive Course on Translating Research into Drugs
San Diego, CA
February 6-8, 2011



ABOUT THE MEETING The purpose of the Drug Discovery for Neurodegeneration course is to advance drug discovery for neurodegenerative diseases by educating  scientists on the process of translating  basic research into novel therapies. 

The course is designed to give participants knowledge and relevant resources about this field of scientific investigation and address the associated barriers and challenges. 

The program will focus on Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis and Multiple Sclerosis.

COURSE OBJECTIVES
  • Train a cadre of interdisciplinary scientists in the principles of drug discovery for neurodegenerative disease;

  • Provide a platform to exchange ideas, knowledge and resources about drug discovery for neurodegenerative disease;

  • Stimulate pre-clinical research in the discovery and testing of novel compounds aimed at the prevention and treatment of neurodegenerative disease; and

  • Build public-private partnerships that will accelerate drug discovery for neurodegenerative disease.


TARGET AUDIENCE
  • Academic and industry scientists engaged in drug discovery research for neurodegenerative disease or CNS

  • Business development and licensing professionals

  • Alliance management professionals

  • Venture capitalists and other investors


For more information visit: http://www.worldeventsforum.com/addf/drugdiscovery/


Table of Contents
PLENARY: The Neurovascular Unit: Biology of Blood Brain Barrier in Neurodegenerative Diseases
I. Basics of Medicinal Chemistry
II. Early Phases of Drug Discovery
III. Pre-Clinical Proof-of-Concept and Development
IV. Issues in Technology Transfer: Interactions and Intellectual Property
V. Beyond Small Molecules: Natural Products, Biologics and Repurposing
VI. Case Studies
VII. Resources and Services For Advancing Drug Discovery


PLENARY: The Neurovascular Unit: Biology of Blood Brain Barrier in Neurodegenerative Diseases

Objectives :

The purpose of the conference is to advance drug discovery for neurodegenerative diseases by educating scientists on the process of translating basic research into novel therapies. 

Speakers and chairs present lectures and case studies on Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, ALS, MS, and other orphan neurological diseases.




______________________

Overview of Drug Discovery for Neurodegenerative Diseases

Speaker(s) : Howard Fillit MD



______________________

The Neurovascular Unit: Biology of Blood Brain Barrier in Neurodegenerative Diseases

Speaker(s) : Berislav Zlokovic MD, PhD





I. Basics of Medicinal Chemistry

Objectives :

The goal of this session is to review fundamentals of medicinal chemistry relevant to drug discovery for CNS disorders. Although the focus is on small molecule drugs, due to the extensive state of knowledge, general themes relevant to peptide and protein therapeutics will also be discussed. The attendee should leave the session with a practical, working familiarity of contemporary approaches and key issues that should be considered by interdisciplinary teams as they take hits to lead compounds to candidate small molecule therapeutics.

______________________

Overview: Medicinal Chemistry Rules of Thumb, Myths and Realities in CNS Drug Discovery

Speaker(s) : D. Martin Watterson, PhD



______________________

Designing Small Molecules with Increased Potential for CNS Penetration

Speaker(s) : Laura Chico, PhD



______________________

Synthetic Chemistry Essentials for Biologists

Speaker(s) : Heather Behanna, PhD



______________________

Structure Assisted Ligand Design

Speaker(s) : Vicki Nienaber, PhD





II. Early Phases of Drug Discovery
______________________

Basics of High Throughput Screening (HTS)

Speaker(s) : James Inglese, PhD



______________________

After HTS: Solubility, Selectivity, Safety and Stability in Addition to Potency

Speaker(s) : Kurt Brunden, PhD



______________________

Importance of Toxicology

Speaker(s) : John E. Sagartz, DVM, PhD





III. Pre-Clinical Proof-of-Concept and Development
______________________

What Makes a Clinical Candidate?

Speaker(s) : William Potter, MD, PhD



______________________

Requirements for an IND

Speaker(s) : Edward Spack, PhD



______________________

The Limitations and Value of Animal Models for Neurodegenerative Disease

Speaker(s) : Steve Perrin, PhD



______________________

Regulatory Requirements in Preparing for Clinical Trials

Speaker(s) : Eric Bastings, MD





IV. Issues in Technology Transfer: Interactions and Intellectual Property
______________________

Working Effectively with Your TTO: Technology Evaluation Process and IP Protection

Speaker(s) : Kathleen Denis, PhD



______________________

Creating Mutually Beneficial Relationships with Industry: Needs, Wants and Paperwork

Speaker(s) : Louis Berneman, EdD



______________________

Should You Start a Biotechnology Company?

Speaker(s) : John S. Swartley, PhD





V. Beyond Small Molecules: Natural Products, Biologics and Repurposing
______________________

Natural Products as Drug Starting Points

Speaker(s) : Frank Koehn, PhD



______________________

Unique Challenges for Biologics

Speaker(s) : Joao Siffert, PhD



______________________

The Road to Repurposing a Drug: Isradipine

Speaker(s) : D. James Surmeier, PhD





VI. Case Studies
______________________

Neurotrophic Factor Mimetics: Target Validation to Lead Optimization

Speaker(s) : Frank Longo, MD, PhD



______________________

Development of Tysabri for Multiple Sclerosis

Speaker(s) : Ted Yednock, MD



______________________

Novel Ways to Reduce Protein Aggregation

Speaker(s) : Alan Snow, PhD





VII. Resources and Services For Advancing Drug Discovery
______________________

Academic Models of Drug Discovery Services & Utilizing CROs

Speaker(s) : Marcie Glicksman, PhD



______________________

Resources at the National Institute of Health

Speaker(s) : Neil Buckholtz, PhD , Rebecca Farkas, PhD




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